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PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase
Telomerase counteracts telomere shortening and cellular senescence in germ, stem, and cancer cells by adding repetitive DNA sequences to the ends of chromosomes. Telomeres are susceptible to damage by reactive oxygen species (ROS), but the consequences of oxidation of telomeres on telomere length an...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004070/ https://www.ncbi.nlm.nih.gov/pubmed/29773556 http://dx.doi.org/10.1101/gad.313460.118 |