Cargando…

Augmented Fibroblast Growth Factor-23 Secretion in Bone Locally Contributes to Impaired Bone Mineralization in Chronic Kidney Disease in Mice

Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a systemic disorder of mineral and bone metabolism caused by CKD. Impaired bone mineralization together with increased bony secretion of fibroblast growth factor-23 (FGF23) are hallmarks of CKD-MBD. We recently showed that FGF23 suppresse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Andrukhova, Olena, Schüler, Christiane, Bergow, Claudia, Petric, Alexandra, Erben, Reinhold G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004378/ https://www.ncbi.nlm.nih.gov/pubmed/29942284 http://dx.doi.org/10.3389/fendo.2018.00311

Ejemplares similares

Excessive Osteocytic Fgf23 Secretion Contributes to Pyrophosphate Accumulation and Mineralization Defect in Hyp Mice
por: Murali, Sathish K., et al.
Publicado: (2016)

Experimental Myocardial Infarction Upregulates Circulating Fibroblast Growth Factor‐23
por: Andrukhova, Olena, et al.
Publicado: (2015)

Physiological Actions of Fibroblast Growth Factor-23
por: Erben, Reinhold G.
Publicado: (2018)

The bone is the major source of high circulating intact fibroblast growth factor-23 in acute murine polymicrobial sepsis induced by cecum ligation puncture
por: Bayer, Jessica, et al.
Publicado: (2021)

Klotho Lacks a Vitamin D Independent Physiological Role in Glucose Homeostasis, Bone Turnover, and Steady-State PTH Secretion In Vivo
por: Anour, René, et al.
Publicado: (2012)

Aldosterone Is Positively Associated With Circulating FGF23 Levels in Chronic Kidney Disease Across Four Species, and May Drive FGF23 Secretion Directly
por: Radloff, Judith, et al.
Publicado: (2021)

α-Klotho's effects on mineral homeostasis are fibroblast growth factor-23 dependent
por: Erben, Reinhold G.
Publicado: (2018)

Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
por: Streicher, Carmen, et al.
Publicado: (2017)

Hypothesis: Coupling between Resorption and Formation in Cancellous bone Remodeling is a Mechanically Controlled Event
por: Erben, Reinhold G.
Publicado: (2015)

Editorial: Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease
por: Erben, Reinhold G.
Publicado: (2019)

Genetic Evidence of Serum Phosphate-Independent Functions of FGF-23 on Bone
por: Sitara, Despina, et al.
Publicado: (2008)

Evaluation of bone mineral density and bone turnover in children on anticoagulation
por: Thom, Katharina, et al.
Publicado: (2023)

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway
por: Andrukhova, Olena, et al.
Publicado: (2012)

Selective inhibition of receptor activator of NF-κB ligand (RANKL) in hematopoietic cells improves outcome after experimental myocardial infarction
por: Slavic, Svetlana, et al.
Publicado: (2018)

FGF23 regulates renal sodium handling and blood pressure
por: Andrukhova, Olena, et al.
Publicado: (2014)

The link between bone-derived factors osteocalcin, fibroblast growth factor 23, sclerostin, lipocalin 2 and tumor bone metastasis
por: Martiniakova, Monika, et al.
Publicado: (2023)

Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population
por: Fu, Yi-Hsiu, et al.
Publicado: (2022)

The Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture
por: Dong, Bingzi, et al.
Publicado: (2022)

Impact of Altered Mineral Metabolism on Pathological Cardiac Remodeling in Elevated Fibroblast Growth Factor 23
por: Leifheit-Nestler, Maren, et al.
Publicado: (2018)

Fibroblast growth factor 23 contributes to diminished bone mineral density in childhood inflammatory bowel disease
por: El-Hodhod, Mostafa Abdel-Aziz, et al.
Publicado: (2012)

Correlation of FGF-23 With Biochemical Markers and Bone Density in Chronic Kidney Disease-Bone Mineral Density Disorder
por: Hussain, Imran, et al.
Publicado: (2023)

Relative Contributions of Lean and Fat Mass to Bone Mineral Density: Insight From Prader-Willi Syndrome
por: Viardot, Alexander, et al.
Publicado: (2018)

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone
por: Li, Junfei, et al.
Publicado: (2022)

Lack of vitamin D signalling per se does not aggravate cardiac functional impairment induced by myocardial infarction in mice
por: Ford, Kristopher, et al.
Publicado: (2018)

Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload
por: Slavic, Svetlana, et al.
Publicado: (2017)

Editorial: Bone marrow adiposity - contributions to bone, aging and beyond
por: Horton, Jason A., et al.
Publicado: (2023)

FGF23 promotes renal calcium reabsorption through the TRPV5 channel
por: Andrukhova, Olena, et al.
Publicado: (2014)

Associations of LRP5 Gene With Bone Mineral Density, Bone Turnover Markers, and Fractures in the Elderly With Osteoporosis
por: Wang, Qi-Fei, et al.
Publicado: (2020)

Twelve New Genomic Loci Associated With Bone Mineral Density
por: Liu, Lu, et al.
Publicado: (2020)

Human Fibroblasts as a Model for the Study of Bone Disorders
por: Claeys, Lauria, et al.
Publicado: (2020)

Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes
por: Yang, Yinqiu, et al.
Publicado: (2018)

Mineral and Bone Consequences of High Dose Denosumab Therapy to Treat an Aneurysmal Bone Cyst, a Child Case Report
por: Del Sindaco, Giulia, et al.
Publicado: (2021)

Perirenalfat thickness is associated with bone turnover markers and bone mineral density in postmenopausal women with type 2 diabetes mellitus
por: Wang, Wei, et al.
Publicado: (2022)

Upstream Regulators of Fibroblast Growth Factor 23
por: Ratsma, Danielle M. A., et al.
Publicado: (2021)

Associations of Serum Cathepsin K and Polymorphisms in CTSK Gene With Bone Mineral Density and Bone Metabolism Markers in Postmenopausal Chinese Women
por: Gao, Li-hong, et al.
Publicado: (2020)

Contribution of immune cells to bone metastasis pathogenesis
por: He, Ningning, et al.
Publicado: (2022)

A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population
por: Dastgheib, Seyed Alireza, et al.
Publicado: (2016)

Evaluation of Bone Mineral Density in Children Conceived via Assisted Reproductive Technology
por: Xia, Xinru, et al.
Publicado: (2022)

Risk Factors Associated With Lower Bone Mineral Density in Primary Aldosteronism Patients
por: Lv, Xiaomei, et al.
Publicado: (2022)

Prolactin is associated with bone mineral density in subjects with type 2 diabetes mellitus
por: Chen, Jia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ca0iumv922ph1nlvjs8h3g799n