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Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5’UTR and PI3K Signaling
The α-secretase “a disintegrin and metalloproteinase domain-containing protein” (ADAM10) is involved in the processing of amyloid precursor protein (APP). Upregulation of ADAM10 precludes the generation of neurotoxic β-amyloid protein (Aβ) and represents a plausible therapeutic strategy for Alzheime...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004422/ https://www.ncbi.nlm.nih.gov/pubmed/29942252 http://dx.doi.org/10.3389/fnmol.2018.00198 |