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Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β(−/−)) murine hearts
INTRODUCTION: Ageing and age-related bioenergetic conditions including obesity, diabetes mellitus and heart failure constitute clinical ventricular arrhythmic risk factors. MATERIALS AND METHODS: Pro-arrhythmic properties in electrocardiographic and intracellular recordings were compared in young an...
Autores principales: | Ahmad, Shiraz, Valli, Haseeb, Chadda, Karan R., Cranley, James, Jeevaratnam, Kamalan, Huang, Christopher L.-H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science Ireland
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004599/ https://www.ncbi.nlm.nih.gov/pubmed/29763629 http://dx.doi.org/10.1016/j.mad.2018.05.004 |
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