Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study

A simple and rapid liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for simultaneous determination of acetaminophen and oxycodone in human plasma. Acetaminophen-d4 and oxycodone-d3 were used as internal standards. The challenge encountered in the method de...

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Detalles Bibliográficos
Autores principales: Lu, Wei, Zhao, Shunbo, Gong, Meng, Sun, Luning, Ding, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004620/
https://www.ncbi.nlm.nih.gov/pubmed/29922484
http://dx.doi.org/10.1016/j.jpha.2018.01.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004620/
https://www.ncbi.nlm.nih.gov/pubmed/29922484
http://dx.doi.org/10.1016/j.jpha.2018.01.006

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