Sensitive and rapid determination of amantadine without derivatization in human plasma by LC–MS/MS for a bioequivalence study

A highly sensitive, rapid and rugged liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method was developed for reliable estimation of amantadine (AMD), an antiviral drug in human plasma. The analyte and internal standard (IS), amantadine-d6 (AMD-d6), were extracted from 200 µL plasma by...

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Detalles Bibliográficos
Autores principales: Bhadoriya, Abhaysingh, Rathnam, Shivprakash, Dasandi, Bhavesh, Parmar, Dharmesh, Sanyal, Mallika, Shrivastav, Pranav S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004625/
https://www.ncbi.nlm.nih.gov/pubmed/29922490
http://dx.doi.org/10.1016/j.jpha.2017.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004625/
https://www.ncbi.nlm.nih.gov/pubmed/29922490
http://dx.doi.org/10.1016/j.jpha.2017.10.003

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