Cargando…

Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents

Parkinson’s disease (PD) is the second most common neurodegenerative disease, affecting approximately one-percent of the population over the age of sixty. Although many animal models have been developed to study this disease, each model presents its own advantages and caveats. A unique model has ari...

Descripción completa

Detalles Bibliográficos
Autores principales:	Polinski, Nicole K., Volpicelli-Daley, Laura A., Sortwell, Caryl E., Luk, Kelvin C., Cremades, Nunilo, Gottler, Lindsey M., Froula, Jessica, Duffy, Megan F., Lee, Virginia M.Y., Martinez, Terina N., Dave, Kuldip D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2018
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004926/ https://www.ncbi.nlm.nih.gov/pubmed/29400668 http://dx.doi.org/10.3233/JPD-171248

Ejemplares similares

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease
por: Gracia, Pablo, et al.
Publicado: (2020)

Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model
por: Stoll, Anna C., et al.
Publicado: (2023)

The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models
por: Polinski, Nicole K., et al.
Publicado: (2022)

A Summary of Phenotypes Observed in the In Vivo Rodent Alpha-Synuclein Preformed Fibril Model
por: Polinski, Nicole K.
Publicado: (2021)

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
por: Duffy, Megan F., et al.
Publicado: (2018)

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
por: Duffy, Megan F., et al.
Publicado: (2018)

Dopaminergic Positron Emission Tomography Imaging in the Alpha‐Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease
por: Sossi, Vesna, et al.
Publicado: (2022)

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau
por: Gracia, Pablo, et al.
Publicado: (2022)

Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease
por: Duffy, Megan F., et al.
Publicado: (2018)

Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity
por: Benskey, Matthew J., et al.
Publicado: (2018)

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
por: Tosatto, Laura, et al.
Publicado: (2015)

Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression
por: Fischer, D. Luke, et al.
Publicado: (2017)

Initiation and propagation of α-synuclein aggregation in the nervous system
por: Hijaz, Baraa A., et al.
Publicado: (2020)

α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons
por: Froula, Jessica M., et al.
Publicado: (2018)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils
por: Redmann, Matthew, et al.
Publicado: (2017)

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
por: Santos, Jaime, et al.
Publicado: (2021)

Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
por: Calabresi, Paolo, et al.
Publicado: (2023)

Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice
por: Boyd, Sierra L, et al.
Publicado: (2023)

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
por: Cascella, Roberta, et al.
Publicado: (2021)

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
por: Xu, Catherine K., et al.
Publicado: (2022)

α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease
por: Cole, Tracy A., et al.
Publicado: (2021)

Ca(2+) is a key factor in α-synuclein-induced neurotoxicity
por: Angelova, Plamena R., et al.
Publicado: (2016)

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
por: Volpicelli-Daley, Laura A., et al.
Publicado: (2014)

Investigating key factors underlying neurodegeneration linked to alpha‐synuclein spread
por: Pang, Cindy C. C., et al.
Publicado: (2022)

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
por: Luk, Kelvin C., et al.
Publicado: (2012)

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
por: Deas, Emma, et al.
Publicado: (2016)

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System
por: Gombash, Sara E., et al.
Publicado: (2013)

Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease
por: Stockdale, Stephen R., et al.
Publicado: (2021)

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing
por: Pedersen, Jeppe T., et al.
Publicado: (2016)

Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
por: Cascella, Roberta, et al.
Publicado: (2022)

Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein
por: Patterson, Joseph R., et al.
Publicado: (2022)

Behavioral and Biochemical Assessment of Monoaminergic Neural Transplants to Rat Frontal Neocortex
por: Sortwell, Caryl E., et al.
Publicado: (1992)

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
por: Cremades, Nunilo, et al.
Publicado: (2012)

The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates
por: Camino, José D., et al.
Publicado: (2020)

BDNF provides many routes toward STN DBS‐mediated disease modification
por: Fischer, D. Luke, et al.
Publicado: (2018)

Distinct biological activity of Lewy body α-Synuclein strain in mice
por: Uemura, Norihito, et al.
Publicado: (2023)

Transmission of alpha-synuclein in Parkinson’s disease
por: Lee, Virginia M-Y
Publicado: (2013)

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models
por: Djelloul, Mehdi, et al.
Publicado: (2015)

Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss
por: Sauerbeck, Andrew D., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pqoorvucs7sdbafvukh81oc7ps