The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson’s disease mouse model

Accumulating evidence suggests that the non-receptor tyrosine kinase c-Abl plays an important role in the progression of Parkinson’s disease (PD) and c-Abl inhibition could be neuroprotective in PD and related α-synucleinopathies. Nilotinib, a c-Abl inhibitor, has shown improved motor and cognitive...

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Detalles Bibliográficos
Autores principales: Lee, Saebom, Kim, Sangjune, Park, Yong Joo, Yun, Seung Pil, Kwon, Seung-Hwan, Kim, Donghoon, Kim, Dong Yeon, Shin, Jae Soo, Cho, Dae Jin, Lee, Gong Yeal, Ju, Hyun Soo, Yun, Hyo Jung, Park, Jae Hong, Kim, Wonjoong Richard, Jung, Eun Ah, Lee, Seulki, Ko, Han Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005030/
https://www.ncbi.nlm.nih.gov/pubmed/29897434
http://dx.doi.org/10.1093/hmg/ddy143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005030/
https://www.ncbi.nlm.nih.gov/pubmed/29897434
http://dx.doi.org/10.1093/hmg/ddy143

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