Mutation EthA(W21R) confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv

Ethionamide (ETA) and prothionamide (PRO) are interchangeably used in tuberculosis (TB) chemotherapy regimens. Subtle discrepancies between biochemical and genetic information on the modes of sensitivity and resistance of isoniazid (INH) and ETA warrants further studies. We report a new mutation – E...

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Autores principales: Mugweru, Julius, Liu, Jianxiong, Makafe, Gaelle, Chiwala, Gift, Wang, Bangxing, Wang, Changwei, Li, Xinjie, Tan, Yaoju, Yew, Wing Wai, Tan, Shouyong, Zhang, Tianyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005328/
https://www.ncbi.nlm.nih.gov/pubmed/29942141
http://dx.doi.org/10.2147/IDR.S163965
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author Mugweru, Julius
Liu, Jianxiong
Makafe, Gaelle
Chiwala, Gift
Wang, Bangxing
Wang, Changwei
Li, Xinjie
Tan, Yaoju
Yew, Wing Wai
Tan, Shouyong
Zhang, Tianyu
author_facet Mugweru, Julius
Liu, Jianxiong
Makafe, Gaelle
Chiwala, Gift
Wang, Bangxing
Wang, Changwei
Li, Xinjie
Tan, Yaoju
Yew, Wing Wai
Tan, Shouyong
Zhang, Tianyu
author_sort Mugweru, Julius
collection PubMed
description Ethionamide (ETA) and prothionamide (PRO) are interchangeably used in tuberculosis (TB) chemotherapy regimens. Subtle discrepancies between biochemical and genetic information on the modes of sensitivity and resistance of isoniazid (INH) and ETA warrants further studies. We report a new mutation – EthA(W21R) – in Mycobacterium bovis Bacillus Calmette-Guérin that corresponds with co-resistance to both PRO and ETA, which to the best of our knowledge has not been reported before. Our findings suggest that mutation EthA(W21R) could be used as a marker site for testing PRO and ETA cross-resistance.
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spelling pubmed-60053282018-06-25 Mutation EthA(W21R) confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv Mugweru, Julius Liu, Jianxiong Makafe, Gaelle Chiwala, Gift Wang, Bangxing Wang, Changwei Li, Xinjie Tan, Yaoju Yew, Wing Wai Tan, Shouyong Zhang, Tianyu Infect Drug Resist Short Report Ethionamide (ETA) and prothionamide (PRO) are interchangeably used in tuberculosis (TB) chemotherapy regimens. Subtle discrepancies between biochemical and genetic information on the modes of sensitivity and resistance of isoniazid (INH) and ETA warrants further studies. We report a new mutation – EthA(W21R) – in Mycobacterium bovis Bacillus Calmette-Guérin that corresponds with co-resistance to both PRO and ETA, which to the best of our knowledge has not been reported before. Our findings suggest that mutation EthA(W21R) could be used as a marker site for testing PRO and ETA cross-resistance. Dove Medical Press 2018-06-13 /pmc/articles/PMC6005328/ /pubmed/29942141 http://dx.doi.org/10.2147/IDR.S163965 Text en © 2018 Mugweru et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Short Report
Mugweru, Julius
Liu, Jianxiong
Makafe, Gaelle
Chiwala, Gift
Wang, Bangxing
Wang, Changwei
Li, Xinjie
Tan, Yaoju
Yew, Wing Wai
Tan, Shouyong
Zhang, Tianyu
Mutation EthA(W21R) confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv
title Mutation EthA(W21R) confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv
title_full Mutation EthA(W21R) confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv
title_fullStr Mutation EthA(W21R) confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv
title_full_unstemmed Mutation EthA(W21R) confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv
title_short Mutation EthA(W21R) confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv
title_sort mutation etha(w21r) confers co-resistance to prothionamide and ethionamide in both mycobacterium bovis bcg and mycobacterium tuberculosis h37rv
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005328/
https://www.ncbi.nlm.nih.gov/pubmed/29942141
http://dx.doi.org/10.2147/IDR.S163965
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