Cargando…
Mutation EthA(W21R) confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv
Ethionamide (ETA) and prothionamide (PRO) are interchangeably used in tuberculosis (TB) chemotherapy regimens. Subtle discrepancies between biochemical and genetic information on the modes of sensitivity and resistance of isoniazid (INH) and ETA warrants further studies. We report a new mutation – E...
Autores principales: | Mugweru, Julius, Liu, Jianxiong, Makafe, Gaelle, Chiwala, Gift, Wang, Bangxing, Wang, Changwei, Li, Xinjie, Tan, Yaoju, Yew, Wing Wai, Tan, Shouyong, Zhang, Tianyu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005328/ https://www.ncbi.nlm.nih.gov/pubmed/29942141 http://dx.doi.org/10.2147/IDR.S163965 |
Ejemplares similares
-
EthA/R-Independent Killing of Mycobacterium tuberculosis by Ethionamide
por: Ang, Michelle L. T., et al.
Publicado: (2017) -
Molecular Characterization of Prothionamide-Resistant Mycobacterium tuberculosis Isolates in Southern China
por: Tan, Yaoju, et al.
Publicado: (2017) -
The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model
por: Liu, Yang, et al.
Publicado: (2019) -
Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance
por: de Welzen, Lynne, et al.
Publicado: (2017) -
Bacterial Genome-Wide Association Identifies Novel Factors That Contribute to Ethionamide and Prothionamide Susceptibility in Mycobacterium tuberculosis
por: Hicks, Nathan D., et al.
Publicado: (2019)