Identification of “sarsasapogenin-aglyconed” timosaponins as novel Aβ-lowering modulators of amyloid precursor protein processing

The inhibition of amyloid β (Aβ) peptide production is a key approach in the development of therapeutics for the treatment of Alzheimer's disease (AD). We have identified that timosaponins consisting of sarsasapogenin (SSG) as the aglycone can effectively lower the production of Aβ peptides and...

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Detalles Bibliográficos
Autores principales: Sy, Lai-King, Lok, Chun-Nam, Wang, Juan-Yu, Liu, Yungen, Cheng, Lu, Wan, Pui-Ki, Leung, Chi-Ting, Cao, Bei, Kwong, Wai-Lun, Chang, Raymond Chuen-Chung, Che, Chi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005341/
https://www.ncbi.nlm.nih.gov/pubmed/29997812
http://dx.doi.org/10.1039/c5sc02377g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005341/
https://www.ncbi.nlm.nih.gov/pubmed/29997812
http://dx.doi.org/10.1039/c5sc02377g

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