Anti-replicative recombinant 5S rRNA molecules can modulate the mtDNA heteroplasmy in a glucose-dependent manner

Mutations in mitochondrial DNA are an important source of severe and incurable human diseases. The vast majority of these mutations are heteroplasmic, meaning that mutant and wild-type genomes are present simultaneously in the same cell. Only a very high proportion of mutant mitochondrial DNA (heter...

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Detalles Bibliográficos
Autores principales: Loutre, Romuald, Heckel, Anne-Marie, Jeandard, Damien, Tarassov, Ivan, Entelis, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005506/
https://www.ncbi.nlm.nih.gov/pubmed/29912984
http://dx.doi.org/10.1371/journal.pone.0199258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005506/
https://www.ncbi.nlm.nih.gov/pubmed/29912984
http://dx.doi.org/10.1371/journal.pone.0199258

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