Mitochondrial dysfunction reduces yeast replicative lifespan by elevating RAS-dependent ROS production by the ER-localized NADPH oxidase Yno1

Mitochondrial dysfunction leads to the accumulation of reactive oxygen species (ROS) which is associated with cellular dysfunction, disease etiology, and senescence. Here, we used the eukaryotic model Saccharomyces cerevisiae, commonly studied for cellular aging, to demonstrate how defective mitocho...

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Detalles Bibliográficos
Autores principales: Yi, Dae-Gwan, Hong, Sujin, Huh, Won-Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005541/
https://www.ncbi.nlm.nih.gov/pubmed/29912878
http://dx.doi.org/10.1371/journal.pone.0198619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005541/
https://www.ncbi.nlm.nih.gov/pubmed/29912878
http://dx.doi.org/10.1371/journal.pone.0198619

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