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(C(2)G(4))(n) repeat expansion sequences from the C9orf72 gene form an unusual DNA higher-order structure in the pH range of 5-6
Massive expansion of a DNA hexanucleotide sequence repeat (C(2)G(4)) within the human C9orf72 gene has been linked to a number of neurodegenerative diseases. In sodium or potassium salt solutions, single-stranded d(C(2)G(4))(n) DNAs fold to form G-quadruplexes. We have found that in magnesium or lit...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005549/ https://www.ncbi.nlm.nih.gov/pubmed/29912891 http://dx.doi.org/10.1371/journal.pone.0198418 |