Cargando…
Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain
The human dopamine transporter (hDAT) is located on presynaptic neurons, where it plays an essential role in limiting dopaminergic signaling by temporarily curtailing high neurotransmitter concentration through rapid re-uptake. Transport by hDAT is energized by transmembrane ionic gradients. Dysfunc...
Autores principales: | Jayaraman, Kumaresan, Morley, Alex N., Szöllősi, Daniel, Wassenaar, Tsjerk A., Sitte, Harald H., Stockner, Thomas |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005636/ https://www.ncbi.nlm.nih.gov/pubmed/29874235 http://dx.doi.org/10.1371/journal.pcbi.1006229 |
Ejemplares similares
-
SLC6 transporter oligomerization
por: Jayaraman, Kumaresan, et al.
Publicado: (2020) -
Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain
por: Gradisch, Ralph, et al.
Publicado: (2022) -
Identifying forces that stabilize the oligomeric state of bacterial homologs of neurotransmitter transporters
por: Jayaraman, Kumaresan, et al.
Publicado: (2012) -
Sodium Binding Stabilizes the Outward-Open State of SERT by Limiting Bundle Domain Motions
por: Szöllősi, Dániel, et al.
Publicado: (2022) -
It takes two—or more—to tango: Revisiting the role of dopamine transporter oligomerization
por: Gether, Ulrik, et al.
Publicado: (2021)