Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION

Macromolecular complexes that exhibit continuous forms of structural flexibility pose a challenge for many existing tools in cryo-EM single-particle analysis. We describe a new tool, called multi-body refinement, which models flexible complexes as a user-defined number of rigid bodies that move inde...

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Detalles Bibliográficos
Autores principales: Nakane, Takanori, Kimanius, Dari, Lindahl, Erik, Scheres, Sjors HW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005684/
https://www.ncbi.nlm.nih.gov/pubmed/29856314
http://dx.doi.org/10.7554/eLife.36861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005684/
https://www.ncbi.nlm.nih.gov/pubmed/29856314
http://dx.doi.org/10.7554/eLife.36861

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