Inducing CCR5Δ32/Δ32 Homozygotes in the Human Jurkat CD4+ Cell Line and Primary CD4+ Cells by CRISPR-Cas9 Genome-Editing Technology

C-C chemokine receptor type 5 (CCR5) is the main co-receptor for HIV entry into the target CD4+ cells, and homozygous CCR5Δ32/Δ32 cells are resistant to CCR5-tropic HIV infection. However, the CCR5Δ32/Δ32 homozygous donors in populations are rare. Here we developed a simple approach to induce CCR5Δ3...

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Detalles Bibliográficos
Autores principales: Qi, Chunxia, Li, Dan, Jiang, Xiangxiang, Jia, Xiaopeng, Lu, Lingling, Wang, Yanfeng, Sun, Jinhuan, Shao, Yiming, Wei, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005807/
https://www.ncbi.nlm.nih.gov/pubmed/30195765
http://dx.doi.org/10.1016/j.omtn.2018.05.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005807/
https://www.ncbi.nlm.nih.gov/pubmed/30195765
http://dx.doi.org/10.1016/j.omtn.2018.05.012

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