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Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing
Protein degradation in all domains of life requires ATPases that unfold and inject proteins into compartmentalized proteolytic chambers. Proteasomal ATPases in eukaryotes and archaea contain poorly understood N-terminally conserved coiled-coil domains. In this study, we engineer disulfide crosslinks...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006169/ https://www.ncbi.nlm.nih.gov/pubmed/29915197 http://dx.doi.org/10.1038/s41467-018-04731-6 |