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Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing

Protein degradation in all domains of life requires ATPases that unfold and inject proteins into compartmentalized proteolytic chambers. Proteasomal ATPases in eukaryotes and archaea contain poorly understood N-terminally conserved coiled-coil domains. In this study, we engineer disulfide crosslinks...

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Detalles Bibliográficos
Autores principales:	Snoberger, Aaron, Brettrager, Evan J., Smith, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006169/ https://www.ncbi.nlm.nih.gov/pubmed/29915197 http://dx.doi.org/10.1038/s41467-018-04731-6

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