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IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K

Interleukin 4 (IL-4) is a critical cytokine implicated with T(H)2 immune reactions, which are linked to pathologic conditions of allergic diseases. In that context, the initiation of T(H)2 responses can critically depend on early basophil-derived IL-4 to activate T-cell responses, which then amplify...

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Detalles Bibliográficos
Autores principales: Reinhart, Ramona, Kaufmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006176/
https://www.ncbi.nlm.nih.gov/pubmed/29915306
http://dx.doi.org/10.1038/s41419-018-0754-z