Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity

Complex tissue-specific and cell-specific signaling by the estrogen receptor (ER) frequently leads to the development of resistance to endocrine therapy for breast cancer. Pure ER antagonists, which completely lack tissue-specific agonist activity, hold promise for preventing and treating endocrine...

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Detalles Bibliográficos
Autores principales: Fanning, S. W., Hodges-Gallagher, L., Myles, D. C., Sun, R., Fowler, C. E., Plant, I. N., Green, B. D., Harmon, C. L., Greene, G. L., Kushner, P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006285/
https://www.ncbi.nlm.nih.gov/pubmed/29915250
http://dx.doi.org/10.1038/s41467-018-04413-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006285/
https://www.ncbi.nlm.nih.gov/pubmed/29915250
http://dx.doi.org/10.1038/s41467-018-04413-3

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