Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice

Acetylcholine contracts the bladder by binding to muscarinic M3 receptors on the detrusor, leading to Ca(2+) influx via voltage-gated Ca(2+) channels. The cellular mechanisms linking these events are poorly understood, but studies have suggested that activation of TRPC4 channels could be involved. T...

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Detalles Bibliográficos
Autores principales: Griffin, Caoimhin S., Thornbury, Keith D., Hollywood, Mark A., Sergeant, Gerard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006323/
https://www.ncbi.nlm.nih.gov/pubmed/29915209
http://dx.doi.org/10.1038/s41598-018-27617-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006323/
https://www.ncbi.nlm.nih.gov/pubmed/29915209
http://dx.doi.org/10.1038/s41598-018-27617-5

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