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Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice
Acetylcholine contracts the bladder by binding to muscarinic M3 receptors on the detrusor, leading to Ca(2+) influx via voltage-gated Ca(2+) channels. The cellular mechanisms linking these events are poorly understood, but studies have suggested that activation of TRPC4 channels could be involved. T...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006323/ https://www.ncbi.nlm.nih.gov/pubmed/29915209 http://dx.doi.org/10.1038/s41598-018-27617-5 |