SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements

The RNA-binding protein SRSF3 (also known as SRp20) has critical roles in the regulation of pre-mRNA splicing. Zygotic knockout of Srsf3 results in embryo arrest at the blastocyst stage. However, SRSF3 is also present in oocytes, suggesting that it might be critical as a maternally inherited factor....

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Detalles Bibliográficos
Autores principales: Do, Dang Vinh, Strauss, Bernhard, Cukuroglu, Engin, Macaulay, Iain, Wee, Keng Boon, Hu, Tim Xiaoming, Igor, Ruiz De Los Mozos, Lee, Caroline, Harrison, Andrew, Butler, Richard, Dietmann, Sabine, Jernej, Ule, Marioni, John, Smith, Christopher W. J., Göke, Jonathan, Surani, M. Azim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006335/
https://www.ncbi.nlm.nih.gov/pubmed/29928511
http://dx.doi.org/10.1038/s41421-018-0032-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006335/
https://www.ncbi.nlm.nih.gov/pubmed/29928511
http://dx.doi.org/10.1038/s41421-018-0032-3

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