Minimization of dynamic effects in the evolution of dihydrofolate reductase

Protein isotope labeling is a powerful technique to probe functionally important motions in enzyme catalysis and can be applied to investigate the conformational dynamics of proteins. Previous investigations have indicated that dynamic coupling is detrimental to catalysis by dihydrofolate reductase...

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Detalles Bibliográficos
Autores principales: Ruiz-Pernía, J. Javier, Behiry, Enas, Luk, Louis Y. P., Loveridge, E. Joel, Tuñón, Iñaki, Moliner, Vicent, Allemann, Rudolf K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006479/
https://www.ncbi.nlm.nih.gov/pubmed/29997817
http://dx.doi.org/10.1039/c5sc04209g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006479/
https://www.ncbi.nlm.nih.gov/pubmed/29997817
http://dx.doi.org/10.1039/c5sc04209g

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