Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation

Peptide stapling emerged as a versatile strategy to recapitulate the bioactive helical conformation of unstructured short peptides in water to improve their therapeutic properties in targeting intracellular “undruggable” targets. Here, we describe the development of photo-induced intramolecular thio...

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Detalles Bibliográficos
Autores principales: Tian, Yuan, Li, Jingxu, Zhao, Hui, Zeng, Xiangze, Wang, Dongyuan, Liu, Qisong, Niu, Xiaogang, Huang, Xuhui, Xu, Naihan, Li, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006495/
https://www.ncbi.nlm.nih.gov/pubmed/29997825
http://dx.doi.org/10.1039/c6sc00106h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006495/
https://www.ncbi.nlm.nih.gov/pubmed/29997825
http://dx.doi.org/10.1039/c6sc00106h

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