Cargando…

High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease

High circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E1-mediated oxidative stress and circulating leptin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alhasson, Firas, Seth, Ratanesh Kumar, Sarkar, Sutapa, Kimono, Diana A., Albadrani, Muayad S., Dattaroy, Diptadip, Chandrashekaran, Varun, Scott, Geoffrey I., Raychoudhury, Samir, Nagarkatti, Mitzi, Nagarkatti, Prakash, Diehl, Anna Mae, Chatterjee, Saurabh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006523/ https://www.ncbi.nlm.nih.gov/pubmed/29660503 http://dx.doi.org/10.1016/j.redox.2018.04.002

Ejemplares similares

HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease
por: Chandrashekaran, Varun, et al.
Publicado: (2017)

Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease
por: Sarkar, Sutapa, et al.
Publicado: (2019)

Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis
por: Mondal, Ayan, et al.
Publicado: (2020)

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation
por: Alhasson, Firas, et al.
Publicado: (2017)

Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis
por: Pourhoseini, Sahar, et al.
Publicado: (2015)

Dysbiosis-Associated Enteric Glial Cell Immune-Activation and Redox Imbalance Modulate Tight Junction Protein Expression in Gulf War Illness Pathology
por: Kimono, Diana, et al.
Publicado: (2019)

TLR Antagonism by Sparstolonin B Alters Microbial Signature and Modulates Gastrointestinal and Neuronal Inflammation in Gulf War Illness Preclinical Model
por: Bose, Dipro, et al.
Publicado: (2020)

Resveratrol Attenuates Allergic Asthma and Associated Inflammation in the Lungs Through Regulation of miRNA-34a That Targets FoxP3 in Mice
por: Alharris, Esraah, et al.
Publicado: (2018)

Corrigendum: Resveratrol attenuates allergic asthma and associated inflammation in the lungs through regulation of miRNA-34a that targets FoxP3 in mice
por: Alharris, Esraah, et al.
Publicado: (2023)

miR-466a Targeting of TGF-β2 Contributes to FoxP3(+) Regulatory T Cell Differentiation in a Murine Model of Allogeneic Transplantation
por: Becker, William, et al.
Publicado: (2018)

Use of Cannabinoids to Treat Acute Respiratory Distress Syndrome and Cytokine Storm Associated with Coronavirus Disease-2019
por: Nagarkatti, Prakash, et al.
Publicado: (2020)

Targeting AhR as a Novel Therapeutic Modality against Inflammatory Diseases
por: Cannon, Alkeiver S., et al.
Publicado: (2021)

Role of Myeloid-Derived Suppressor Cells in Amelioration of Experimental Autoimmune Hepatitis Following Activation of TRPV1 Receptors by Cannabidiol
por: Hegde, Venkatesh L., et al.
Publicado: (2011)

Anandamide Attenuates Th-17 Cell-Mediated Delayed-Type Hypersensitivity Response by Triggering IL-10 Production and Consequent microRNA Induction
por: Jackson, Austin R., et al.
Publicado: (2014)

Prediction of Possible Biomarkers and Novel Pathways Conferring Risk to Post-Traumatic Stress Disorder
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2016)

Natural Indoles, Indole-3-Carbinol (I3C) and 3,3’-Diindolylmethane (DIM), Attenuate Staphylococcal Enterotoxin B-Mediated Liver Injury by Downregulating miR-31 Expression and Promoting Caspase-2-Mediated Apoptosis
por: Busbee, Philip B., et al.
Publicado: (2015)

From Suppressor T Cells to Regulatory T Cells: How the Journey that Began with the Discovery of the Toxic Effects of TCDD Led to Better Understanding of the Role of AhR in Immunoregulation
por: Prasad Singh, Narendra, et al.
Publicado: (2020)

Regulation of Intestinal Stem Cell Stemness by the Aryl Hydrocarbon Receptor and Its Ligands
por: Wisniewski, Paul J., et al.
Publicado: (2021)

Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases
por: Holloman, Bryan Latrell, et al.
Publicado: (2021)

Role of Gut Microbiota in Cannabinoid-Mediated Suppression of Inflammation
por: Varsha, Kontham Kulangara, et al.
Publicado: (2022)

Cannabidiol Regulates Gene Expression in Encephalitogenic T cells Using Histone Methylation and noncoding RNA during Experimental Autoimmune Encephalomyelitis
por: Yang, Xiaoming, et al.
Publicado: (2019)

Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells
por: Elliott, David M., et al.
Publicado: (2018)

Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells
por: Alharris, Esraah, et al.
Publicado: (2019)

Analysis of the TP53 Deleterious Single Nucleotide Polymorphisms Impact on Estrogen Receptor Alpha-p53 Interaction: A Machine Learning Approach
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2019)

Comparative analysis of interactions between aryl hydrocarbon receptor ligand binding domain with its ligands: a computational study
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2018)

Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells
por: Miranda, Kathryn, et al.
Publicado: (2019)

Combination of Cannabinoids, Δ9- Tetrahydrocannabinol and Cannabidiol, Ameliorates Experimental Multiple Sclerosis by Suppressing Neuroinflammation Through Regulation of miRNA-Mediated Signaling Pathways
por: Al-Ghezi, Zinah Zamil, et al.
Publicado: (2019)

The role of gut microbiota in shaping the relapse-remitting and chronic-progressive forms of multiple sclerosis in mouse models
por: Gandy, K. Alexa Orr, et al.
Publicado: (2019)

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces multigenerational alterations in the expression of microRNA in the thymus through epigenetic modifications
por: Singh, Narendra P, et al.
Publicado: (2022)

Aryl Hydrocarbon Receptor Activation Ameliorates Acute Respiratory Distress Syndrome through Regulation of Th17 and Th22 Cells in the Lungs
por: Holloman, Bryan Latrell, et al.
Publicado: (2023)

Resveratrol Prevents Endothelial Cells Injury in High-Dose Interleukin-2 Therapy against Melanoma
por: Guan, Hongbing, et al.
Publicado: (2012)

Prenatal Exposure to TCDD Triggers Significant Modulation of microRNA Expression Profile in the Thymus That Affects Consequent Gene Expression
por: Singh, Narendra P., et al.
Publicado: (2012)

The Ability of Resveratrol to Attenuate Ovalbumin-Mediated Allergic Asthma Is Associated With Changes in Microbiota Involving the Gut-Lung Axis, Enhanced Barrier Function and Decreased Inflammation in the Lungs
por: Alharris, Esraah, et al.
Publicado: (2022)

Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor
por: Dopkins, Nicholas, et al.
Publicado: (2021)

Taming the beast within: resveratrol suppresses colitis and prevents colon cancer
por: Hofseth, Lorne J., et al.
Publicado: (2010)

Withaferin A Associated Differential Regulation of Inflammatory Cytokines
por: Dubey, Seema, et al.
Publicado: (2018)

MicroRNA-30 modulates metabolic inflammation by regulating notch signaling in adipose tissue macrophages
por: Miranda, Kathryn, et al.
Publicado: (2018)

Alterations in the Gut Microbiome and Suppression of Histone Deacetylases by Resveratrol Are Associated with Attenuation of Colonic Inflammation and Protection Against Colorectal Cancer
por: Alrafas, Haider Rasheed, et al.
Publicado: (2020)

Administration of Δ9‐Tetrahydrocannabinol (THC) Post‐Staphylococcal Enterotoxin B Exposure Protects Mice From Acute Respiratory Distress Syndrome and Toxicity
por: Mohammed, Amira, et al.
Publicado: (2020)

Protective effects of Δ(9)‐tetrahydrocannabinol against enterotoxin‐induced acute respiratory distress syndrome are mediated by modulation of microbiota
por: Mohammed, Amira, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gpgnha70h4p87p5j2g7ehii1b5