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Clonal dynamics studied in cultured induced pluripotent stem cells reveal major growth imbalances within a few weeks

BACKGROUND: Human induced pluripotent stem (iPS) cells have revolutionised research and spark hopes for future tissue replacement therapies. To obtain high cell numbers, iPS cells can be expanded indefinitely. However, as long-term expansion can compromise cell integrity and quality, we set out to a...

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Detalles Bibliográficos
Autores principales: Brenière-Letuffe, David, Domke-Shibamiya, Aya, Hansen, Arne, Eschenhagen, Thomas, Fehse, Boris, Riecken, Kristoffer, Stenzig, Justus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006556/
https://www.ncbi.nlm.nih.gov/pubmed/29914569
http://dx.doi.org/10.1186/s13287-018-0893-2