Cargando…

A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1

It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them have been shown also to have neuroprotective...

Descripción completa

Detalles Bibliográficos
Autores principales:	Testa, Gabriella, Staurenghi, Erica, Giannelli, Serena, Gargiulo, Simona, Guglielmotto, Michela, Tabaton, Massimo, Tamagno, Elena, Gamba, Paola, Leonarduzzi, Gabriella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007083/ https://www.ncbi.nlm.nih.gov/pubmed/29883958 http://dx.doi.org/10.1016/j.redox.2018.05.009

Ejemplares similares

The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease
por: Gamba, Paola, et al.
Publicado: (2021)

Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine
por: Gamba, Paola, et al.
Publicado: (2014)

24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer’s Disease
por: Testa, Gabriella, et al.
Publicado: (2023)

The role of autophagy in survival response induced by 27-hydroxycholesterol in human promonocytic cells
por: Vurusaner, Beyza, et al.
Publicado: (2018)

A Crosstalk Between Brain Cholesterol Oxidation and Glucose Metabolism in Alzheimer’s Disease
por: Gamba, Paola, et al.
Publicado: (2019)

Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?
por: Staurenghi, Erica, et al.
Publicado: (2021)

Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease
por: Gamba, Paola, et al.
Publicado: (2015)

Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability
por: Gargiulo, Simona, et al.
Publicado: (2015)

ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis
por: Staurenghi, Erica, et al.
Publicado: (2022)

Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation
por: Testa, Gabriella, et al.
Publicado: (2016)

Oxidative Stress Mediates the Pathogenic Effect of Different Alzheimer's Disease Risk Factors
por: Guglielmotto, Michela, et al.
Publicado: (2010)

Oxidative Stress and Beta Amyloid in Alzheimer’s Disease. Which Comes First: The Chicken or the Egg?
por: Tamagno, Elena, et al.
Publicado: (2021)

Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol
por: Civra, Andrea, et al.
Publicado: (2014)

Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2
por: Staurenghi, Erica, et al.
Publicado: (2020)

The Unexpected Role of Aβ(1-42) Monomers in the Pathogenesis of Alzheimer’s Disease
por: Tamagno, Elena, et al.
Publicado: (2018)

25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes
por: Civra, Andrea, et al.
Publicado: (2018)

The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer’s and Vascular Disease
por: Guglielmotto, Michela, et al.
Publicado: (2017)

Molecular Signaling Involved in Oxysterol-Induced β(1)-Integrin Over-Expression in Human Macrophages
por: Gargiulo, Simona, et al.
Publicado: (2012)

Estrogens still represent an attractive therapeutic approach for Alzheimer’s disease
por: Tamagno, Elena, et al.
Publicado: (2021)

Loading into Nanoparticles Improves Quercetin's Efficacy in Preventing Neuroinflammation Induced by Oxysterols
por: Testa, Gabriella, et al.
Publicado: (2014)

Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model
por: Ishikawa, Makoto, et al.
Publicado: (2018)

Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin
por: Guglielmotto, Michela, et al.
Publicado: (2009)

Beta‐amyloid 1‐42 monomers, but not oligomers, produce PHF‐like conformation of Tau protein
por: Manassero, Giusi, et al.
Publicado: (2016)

Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum
por: Bandaru, Veera Venkata Ratnam, et al.
Publicado: (2014)

24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation
por: Sun, Min-Yu, et al.
Publicado: (2017)

Regulation of Th17/Treg Balance by 27-Hydroxycholesterol and 24S-Hydroxycholesterol Correlates with Learning and Memory Ability in Mice
por: Wang, Tao, et al.
Publicado: (2022)

Assessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia
por: Chiappelli, Joshua, et al.
Publicado: (2020)

24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventional cell death
por: Urano, Yasuomi, et al.
Publicado: (2019)

Population pharmacokinetics, enzyme occupancy, and 24S‐hydroxycholesterol modeling of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, in healthy adults
por: Yin, Wei, et al.
Publicado: (2023)

Wine consumption and intestinal redox homeostasis
por: Biasi, Fiorella, et al.
Publicado: (2014)

Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3
por: Gc, Jeevan B., et al.
Publicado: (2023)

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells
por: Prasanthi, Jaya RP, et al.
Publicado: (2009)

Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol
por: Cagno, Valeria, et al.
Publicado: (2017)

Neuroprotective Potential of Dendritic Cells and Sirtuins in Multiple Sclerosis
por: Piacente, Francesco, et al.
Publicado: (2022)

Excitotoxicity increases the release of 24S-hydroxycholesterol via CYP46A1 activation
por: Sodero, Alejandro, et al.
Publicado: (2013)

24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome
por: Björkhem, Ingemar, et al.
Publicado: (2018)

Integrated stress response is involved in the 24(S)-hydroxycholesterol-induced unconventional cell death mechanism
por: Urano, Yasuomi, et al.
Publicado: (2022)

Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro
por: Kamble, Nitin, et al.
Publicado: (2023)

Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study
por: Zuliani, Giovanni, et al.
Publicado: (2011)

Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models
por: Vasciaveo, Valeria, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fsmaeb29lluddc6fs51ahs776t