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X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism
Men are much more likely than women to develop bladder cancer (BCa), but the underlying cause of this gender disparity remains poorly defined. Using sex-reversed mice, we show that the sex chromosome complement is an independent cause and, moreover, amplifies the biasing effects of sex hormones. We...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007159/ https://www.ncbi.nlm.nih.gov/pubmed/29928692 http://dx.doi.org/10.1126/sciadv.aar5598 |