Cargando…

Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells

RNA 3′ polyadenylation is known to serve diverse purposes in biology, in particular, regulating mRNA stability and translation. Here we determined that, upon exposure to high levels of the intercalating agent ethidium bromide (EtBr), greater than those required to suppress mitochondrial transcriptio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toompuu, Marina, Tuomela, Tea, Laine, Pia, Paulin, Lars, Dufour, Eric, Jacobs, Howard T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007314/ https://www.ncbi.nlm.nih.gov/pubmed/29518244 http://dx.doi.org/10.1093/nar/gky159

Ejemplares similares

Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs
por: Shinoda, Saori, et al.
Publicado: (2019)

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs
por: Van Haute, Lindsey, et al.
Publicado: (2019)

Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases
por: Tomoda, Ena, et al.
Publicado: (2023)

Small but large enough: structural properties of armless mitochondrial tRNAs from the nematode Romanomermis culicivorax
por: Jühling, Tina, et al.
Publicado: (2018)

Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome
por: Tosar, Juan Pablo, et al.
Publicado: (2020)

Identification of host tRNAs preferentially recognized by the Plasmodium surface protein tRip
por: Cela, Marta, et al.
Publicado: (2021)

Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs
por: Thivierge, Caroline, et al.
Publicado: (2018)

Dimerization confers increased stability to nucleases in 5′ halves from glycine and glutamic acid tRNAs
por: Tosar, Juan Pablo, et al.
Publicado: (2018)

Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins
por: Torres, Adrian Gabriel, et al.
Publicado: (2021)

Different modification pathways for m(1)A58 incorporation in yeast elongator and initiator tRNAs
por: Yared, Marcel-Joseph, et al.
Publicado: (2023)

Archaeal NSUN6 catalyzes m(5)C72 modification on a wide-range of specific tRNAs
por: Li, Jing, et al.
Publicado: (2019)

The nature of the purine at position 34 in tRNAs of 4-codon boxes is correlated with nucleotides at positions 32 and 38 to maintain decoding fidelity
por: Pernod, Ketty, et al.
Publicado: (2020)

Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNA(Met), all 8 tRNAs and ND6 mRNA in the light-strand transcript
por: Zhao, Xiaoxu, et al.
Publicado: (2019)

hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles
por: Fischl, Harry, et al.
Publicado: (2019)

Polycytidylation of mitochondrial mRNAs in Chlamydomonas reinhardtii
por: Salinas-Giegé, Thalia, et al.
Publicado: (2017)

hnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner
por: Kajitani, Naoko, et al.
Publicado: (2017)

SWI/SNF interacts with cleavage and polyadenylation factors and facilitates pre-mRNA 3′ end processing
por: Yu, Simei, et al.
Publicado: (2018)

The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity
por: Grozdanov, Petar N, et al.
Publicado: (2018)

Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade
por: Tseng, Hsin-Wei, et al.
Publicado: (2022)

Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs
por: Mino, Takashi, et al.
Publicado: (2019)

Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response
por: Murphy, Michael R, et al.
Publicado: (2023)

Polynucleotide phosphorylase promotes the stability and function of Hfq-binding sRNAs by degrading target mRNA-derived fragments
por: Cameron, Todd A, et al.
Publicado: (2019)

Developmental regulation of edited CYb and COIII mitochondrial mRNAs is achieved by distinct mechanisms in Trypanosoma brucei
por: Smith Jr., Joseph T, et al.
Publicado: (2020)

SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m(6)A-modified mRNAs
por: Hou, Guofang, et al.
Publicado: (2021)

Asymmetrical effects of deafness-associated mitochondrial DNA 7516delA mutation on the processing of RNAs in the H-strand and L-strand polycistronic transcripts
por: Xiao, Yun, et al.
Publicado: (2020)

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs
por: Suzuki, Takeo, et al.
Publicado: (2014)

Telomerase RNAs in land plants
por: Fajkus, Petr, et al.
Publicado: (2019)

Determinants of the temperature adaptation of mRNA degradation
por: Jaquet, Vincent, et al.
Publicado: (2022)

TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes
por: Lee, Eliza S, et al.
Publicado: (2020)

Role of ribosome assembly in Escherichia coli ribosomal RNA degradation
por: Jain, Chaitanya
Publicado: (2018)

KREH1 RNA helicase activity promotes utilization of initiator gRNAs across multiple mRNAs in trypanosome RNA editing
por: Dubey, Ashutosh P, et al.
Publicado: (2023)

Transcription feedback dynamics in the wake of cytoplasmic mRNA degradation shutdown
por: Chappleboim, Alon, et al.
Publicado: (2022)

Design and application of circular RNAs with protein-sponge function
por: Schreiner, Silke, et al.
Publicado: (2020)

Allosteric regulation of noncoding RNA function by microRNAs
por: Gorbea, Carlos, et al.
Publicado: (2022)

Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNA(Leu(UUR)) with a pathogenic A2748G mutation
por: Tani, Haruna, et al.
Publicado: (2022)

MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs
por: Sun, Qinyu, et al.
Publicado: (2018)

Intrinsic and regulated properties of minimally edited trypanosome mRNAs
por: Tylec, Brianna L, et al.
Publicado: (2019)

Cis regulation within a cluster of viral microRNAs
por: Vilimova, Monika, et al.
Publicado: (2021)

Evolution of plant telomerase RNAs: farther to the past, deeper to the roots
por: Fajkus, Petr, et al.
Publicado: (2021)

On the rules of engagement for microRNAs targeting protein coding regions
por: Sapkota, Sunil, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cnur7i7qhjc32p2fvi9mm6q2sp