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Complex repeat structure promotes hyper-amplification and amplicon evolution through rolling-circle replication

Inverted repeats (IRs) are abundant in genomes and frequently serve as substrates for chromosomal aberrations, including gene amplification. In the early stage of amplification, repeated cycles of chromosome breakage and rearrangement, called breakage-fusion-bridge (BFB), generate a large inverted s...

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Detalles Bibliográficos
Autores principales: Watanabe, Takaaki, Tanaka, Hisashi, Horiuchi, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007334/
https://www.ncbi.nlm.nih.gov/pubmed/29718479
http://dx.doi.org/10.1093/nar/gky275