Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16(INK4a)-deficient epithelial cells

Telomere dysfunction drives chromosome instability through endless breakage-fusion-bridge (BFB) cycles that promote the formation of highly rearranged genomes. However, reactivation of telomerase or ALT-pathway is required for genome stabilisation and full malignant transformation. To allow the unre...

Descripción completa

Detalles Bibliográficos
Autores principales: Bernal, Aina, Moltó-Abad, Marc, Domínguez, Daniel, Tusell, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007466/
https://www.ncbi.nlm.nih.gov/pubmed/29930757
http://dx.doi.org/10.18632/oncotarget.25502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007466/
https://www.ncbi.nlm.nih.gov/pubmed/29930757
http://dx.doi.org/10.18632/oncotarget.25502

Ejemplares similares