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Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16(INK4a)-deficient epithelial cells
Telomere dysfunction drives chromosome instability through endless breakage-fusion-bridge (BFB) cycles that promote the formation of highly rearranged genomes. However, reactivation of telomerase or ALT-pathway is required for genome stabilisation and full malignant transformation. To allow the unre...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007466/ https://www.ncbi.nlm.nih.gov/pubmed/29930757 http://dx.doi.org/10.18632/oncotarget.25502 |