Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors

The receptor tyrosine kinase MET and its ligand, the Hepatocyte Growth Factor/Scattor Factor (HGF/SF), are essential to the migration, morphogenesis, and survival of epithelial cells. In addition, dysregulation of MET signaling has been shown to promote tumor progression and invasion in many cancers...

Descripción completa

Detalles Bibliográficos
Autores principales: Mekki, Meriem Sarah, Mougel, Alexandra, Vinchent, Audrey, Paquet, Charlotte, Copin, Marie-Christine, Leroy, Catherine, Kherrouche, Zoulika, Bonte, Jean-Paul, Melnyk, Oleg, Vicogne, Jérôme, Tulasne, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007473/
https://www.ncbi.nlm.nih.gov/pubmed/29930749
http://dx.doi.org/10.18632/oncotarget.25472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007473/
https://www.ncbi.nlm.nih.gov/pubmed/29930749
http://dx.doi.org/10.18632/oncotarget.25472

Ejemplares similares