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Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors

The receptor tyrosine kinase MET and its ligand, the Hepatocyte Growth Factor/Scattor Factor (HGF/SF), are essential to the migration, morphogenesis, and survival of epithelial cells. In addition, dysregulation of MET signaling has been shown to promote tumor progression and invasion in many cancers...

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Detalles Bibliográficos
Autores principales:	Mekki, Meriem Sarah, Mougel, Alexandra, Vinchent, Audrey, Paquet, Charlotte, Copin, Marie-Christine, Leroy, Catherine, Kherrouche, Zoulika, Bonte, Jean-Paul, Melnyk, Oleg, Vicogne, Jérôme, Tulasne, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007473/ https://www.ncbi.nlm.nih.gov/pubmed/29930749 http://dx.doi.org/10.18632/oncotarget.25472

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