miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5′ end from the cellular pyrophosphatases, DOM3Z and DUSP11

Hepatitis C virus (HCV) recruits two molecules of the liver-specific microRNA-122 (miR-122) to the 5′ end of its genome. This interaction promotes viral RNA accumulation, but the precise mechanism(s) remain incompletely understood. Previous studies suggest that miR-122 is able to protect the HCV gen...

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Detalles Bibliográficos
Autores principales: Amador-Cañizares, Yalena, Bernier, Annie, Wilson, Joyce A, Sagan, Selena M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007490/
https://www.ncbi.nlm.nih.gov/pubmed/29672716
http://dx.doi.org/10.1093/nar/gky273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007490/
https://www.ncbi.nlm.nih.gov/pubmed/29672716
http://dx.doi.org/10.1093/nar/gky273

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