Single dose of propofol causing propofol infusion syndrome in a newborn

Propofol infusion syndrome (PRIS) is a rare syndrome originally described in critically ill children undergoing long-term (> 48 h) propofol infusion at high doses (> 4 mg/kg/h). Severe metabolic acidosis, rhabdomyolysis, renal failure and fatal cardiac failure are the features. Herein, we pres...

Descripción completa

Detalles Bibliográficos
Autores principales: Michel-Macías, C, Morales-Barquet, D A, Reyes-Palomino, A M, Machuca-Vaca, J A, Orozco-Guillén, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007798/
https://www.ncbi.nlm.nih.gov/pubmed/29942532
http://dx.doi.org/10.1093/omcr/omy023
_version_ 1783333097475932160
author Michel-Macías, C
Morales-Barquet, D A
Reyes-Palomino, A M
Machuca-Vaca, J A
Orozco-Guillén, A
author_facet Michel-Macías, C
Morales-Barquet, D A
Reyes-Palomino, A M
Machuca-Vaca, J A
Orozco-Guillén, A
author_sort Michel-Macías, C
collection PubMed
description Propofol infusion syndrome (PRIS) is a rare syndrome originally described in critically ill children undergoing long-term (> 48 h) propofol infusion at high doses (> 4 mg/kg/h). Severe metabolic acidosis, rhabdomyolysis, renal failure and fatal cardiac failure are the features. Herein, we present a case of a newborn who developed PRIS after a single bolus dose of propofol at 3.2 mg/kg/do, developing rhabdomyolysis and severe metabolic acidosis, with a successful outcome after medical therapy.
format Online
Article
Text
id pubmed-6007798
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-60077982018-06-25 Single dose of propofol causing propofol infusion syndrome in a newborn Michel-Macías, C Morales-Barquet, D A Reyes-Palomino, A M Machuca-Vaca, J A Orozco-Guillén, A Oxf Med Case Reports Case Report Propofol infusion syndrome (PRIS) is a rare syndrome originally described in critically ill children undergoing long-term (> 48 h) propofol infusion at high doses (> 4 mg/kg/h). Severe metabolic acidosis, rhabdomyolysis, renal failure and fatal cardiac failure are the features. Herein, we present a case of a newborn who developed PRIS after a single bolus dose of propofol at 3.2 mg/kg/do, developing rhabdomyolysis and severe metabolic acidosis, with a successful outcome after medical therapy. Oxford University Press 2018-06-18 /pmc/articles/PMC6007798/ /pubmed/29942532 http://dx.doi.org/10.1093/omcr/omy023 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Michel-Macías, C
Morales-Barquet, D A
Reyes-Palomino, A M
Machuca-Vaca, J A
Orozco-Guillén, A
Single dose of propofol causing propofol infusion syndrome in a newborn
title Single dose of propofol causing propofol infusion syndrome in a newborn
title_full Single dose of propofol causing propofol infusion syndrome in a newborn
title_fullStr Single dose of propofol causing propofol infusion syndrome in a newborn
title_full_unstemmed Single dose of propofol causing propofol infusion syndrome in a newborn
title_short Single dose of propofol causing propofol infusion syndrome in a newborn
title_sort single dose of propofol causing propofol infusion syndrome in a newborn
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007798/
https://www.ncbi.nlm.nih.gov/pubmed/29942532
http://dx.doi.org/10.1093/omcr/omy023
work_keys_str_mv AT michelmaciasc singledoseofpropofolcausingpropofolinfusionsyndromeinanewborn
AT moralesbarquetda singledoseofpropofolcausingpropofolinfusionsyndromeinanewborn
AT reyespalominoam singledoseofpropofolcausingpropofolinfusionsyndromeinanewborn
AT machucavacaja singledoseofpropofolcausingpropofolinfusionsyndromeinanewborn
AT orozcoguillena singledoseofpropofolcausingpropofolinfusionsyndromeinanewborn

Ejemplares similares