Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer

Prediction of drug combinations that effectively target cancer cells is a critical challenge for cancer therapy, in particular for triple-negative breast cancer (TNBC), a highly aggressive breast cancer subtype with no effective targeted treatment. As signalling pathway networks critically control c...

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Detalles Bibliográficos
Autores principales: Shin, Sung-Young, Müller, Anna-Katharina, Verma, Nandini, Lev, Sima, Nguyen, Lan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007894/
https://www.ncbi.nlm.nih.gov/pubmed/29920512
http://dx.doi.org/10.1371/journal.pcbi.1006192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007894/
https://www.ncbi.nlm.nih.gov/pubmed/29920512
http://dx.doi.org/10.1371/journal.pcbi.1006192

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