Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

Acyl-coenzyme A (CoA) ligases catalyze the activation of carboxylic acids via a two-step reaction of adenylation followed by thioesterification. Here, we report the discovery of a non-adenylating acyl-CoA ligase PtmA2 and the functional separation of an acyl-CoA ligase reaction. Both PtmA1 and PtmA2...

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Detalles Bibliográficos
Autores principales: Wang, Nan, Rudolf, Jeffrey D., Dong, Liao-Bin, Osipiuk, Jerzy, Hatzos-Skintges, Catherine, Endres, Michael, Chang, Chin-Yuan, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008203/
https://www.ncbi.nlm.nih.gov/pubmed/29867143
http://dx.doi.org/10.1038/s41589-018-0061-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008203/
https://www.ncbi.nlm.nih.gov/pubmed/29867143
http://dx.doi.org/10.1038/s41589-018-0061-0

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