Cargando…
Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations
BACKGROUND & AIMS: Continual renewal of the intestinal epithelium is dependent on active- and slow-cycling stem cells that are confined to the crypt base. Tight regulation of these stem cell populations maintains homeostasis by balancing proliferation and differentiation to support critical inte...
Autores principales: | Smith, Nicholas R., Swain, John R., Davies, Paige S., Gallagher, Alexandra C., Parappilly, Michael S., Beach, Catherine Z., Streeter, Philip R., Williamson, Ian A., Magness, Scott T., Wong, Melissa H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008251/ https://www.ncbi.nlm.nih.gov/pubmed/29928673 http://dx.doi.org/10.1016/j.jcmgh.2018.02.007 |
Ejemplares similares
-
Progastrin production transitions from Bmi1(+)/Prox1(+) to Lgr5(high) cells during early intestinal tumorigenesis
por: Giraud, J., et al.
Publicado: (2020) -
LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/β-Catenin Signaling
por: Li, Xiang-Guang, et al.
Publicado: (2018) -
Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells
por: Srinivasan, Tara, et al.
Publicado: (2016) -
Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion
por: Yanai, Hirotsugu, et al.
Publicado: (2017) -
Inflammation and Proliferation Act Together to Mediate Intestinal Cell Fusion
por: Davies, Paige S., et al.
Publicado: (2009)