Thioamide substitution to probe the hydroxyproline recognition of VHL ligands

Thioamide substitution influences hydrogen bond and n → π(∗) interactions involved in the conformational stability of protein secondary structures and oligopeptides. Hydroxyproline is the key recognition element of small molecules targeting the von Hippel-Lindau (VHL) E3 ligase, which are of interes...

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Detalles Bibliográficos
Autores principales: Soares, Pedro, Lucas, Xavier, Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008493/
https://www.ncbi.nlm.nih.gov/pubmed/29650462
http://dx.doi.org/10.1016/j.bmc.2018.03.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008493/
https://www.ncbi.nlm.nih.gov/pubmed/29650462
http://dx.doi.org/10.1016/j.bmc.2018.03.034

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