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Thioamide substitution to probe the hydroxyproline recognition of VHL ligands
Thioamide substitution influences hydrogen bond and n → π(∗) interactions involved in the conformational stability of protein secondary structures and oligopeptides. Hydroxyproline is the key recognition element of small molecules targeting the von Hippel-Lindau (VHL) E3 ligase, which are of interes...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008493/ https://www.ncbi.nlm.nih.gov/pubmed/29650462 http://dx.doi.org/10.1016/j.bmc.2018.03.034 |