Adverse Effects of Immunoglobulin Therapy
Immunoglobulin has been widely used in a variety of diseases, including primary and secondary immunodeficiency diseases, neuromuscular diseases, and Kawasaki disease. Although a large number of clinical trials have demonstrated that immunoglobulin is effective and well tolerated, various adverse eff...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008653/ https://www.ncbi.nlm.nih.gov/pubmed/29951056 http://dx.doi.org/10.3389/fimmu.2018.01299 |
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author | Guo, Yi Tian, Xin Wang, Xuefeng Xiao, Zheng |
author_facet | Guo, Yi Tian, Xin Wang, Xuefeng Xiao, Zheng |
author_sort | Guo, Yi |
collection | PubMed |
description | Immunoglobulin has been widely used in a variety of diseases, including primary and secondary immunodeficiency diseases, neuromuscular diseases, and Kawasaki disease. Although a large number of clinical trials have demonstrated that immunoglobulin is effective and well tolerated, various adverse effects have been reported. The majority of these events, such as flushing, headache, malaise, fever, chills, fatigue and lethargy, are transient and mild. However, some rare side effects, including renal impairment, thrombosis, arrhythmia, aseptic meningitis, hemolytic anemia, and transfusion-related acute lung injury (TRALI), are serious. These adverse effects are associated with specific immunoglobulin preparations and individual differences. Performing an early assessment of risk factors, infusing at a slow rate, premedicating, and switching from intravenous immunoglobulin (IVIG) to subcutaneous immunoglobulin (SCIG) can minimize these adverse effects. Adverse effects are rarely disabling or fatal, treatment mainly involves supportive measures, and the majority of affected patients have a good prognosis. |
format | Online Article Text |
id | pubmed-6008653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60086532018-06-27 Adverse Effects of Immunoglobulin Therapy Guo, Yi Tian, Xin Wang, Xuefeng Xiao, Zheng Front Immunol Immunology Immunoglobulin has been widely used in a variety of diseases, including primary and secondary immunodeficiency diseases, neuromuscular diseases, and Kawasaki disease. Although a large number of clinical trials have demonstrated that immunoglobulin is effective and well tolerated, various adverse effects have been reported. The majority of these events, such as flushing, headache, malaise, fever, chills, fatigue and lethargy, are transient and mild. However, some rare side effects, including renal impairment, thrombosis, arrhythmia, aseptic meningitis, hemolytic anemia, and transfusion-related acute lung injury (TRALI), are serious. These adverse effects are associated with specific immunoglobulin preparations and individual differences. Performing an early assessment of risk factors, infusing at a slow rate, premedicating, and switching from intravenous immunoglobulin (IVIG) to subcutaneous immunoglobulin (SCIG) can minimize these adverse effects. Adverse effects are rarely disabling or fatal, treatment mainly involves supportive measures, and the majority of affected patients have a good prognosis. Frontiers Media S.A. 2018-06-08 /pmc/articles/PMC6008653/ /pubmed/29951056 http://dx.doi.org/10.3389/fimmu.2018.01299 Text en Copyright © 2018 Guo, Tian, Wang and Xiao. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Guo, Yi Tian, Xin Wang, Xuefeng Xiao, Zheng Adverse Effects of Immunoglobulin Therapy |
title | Adverse Effects of Immunoglobulin Therapy |
title_full | Adverse Effects of Immunoglobulin Therapy |
title_fullStr | Adverse Effects of Immunoglobulin Therapy |
title_full_unstemmed | Adverse Effects of Immunoglobulin Therapy |
title_short | Adverse Effects of Immunoglobulin Therapy |
title_sort | adverse effects of immunoglobulin therapy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008653/ https://www.ncbi.nlm.nih.gov/pubmed/29951056 http://dx.doi.org/10.3389/fimmu.2018.01299 |
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