Adverse Effects of Immunoglobulin Therapy

Immunoglobulin has been widely used in a variety of diseases, including primary and secondary immunodeficiency diseases, neuromuscular diseases, and Kawasaki disease. Although a large number of clinical trials have demonstrated that immunoglobulin is effective and well tolerated, various adverse eff...

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Autores principales: Guo, Yi, Tian, Xin, Wang, Xuefeng, Xiao, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008653/
https://www.ncbi.nlm.nih.gov/pubmed/29951056
http://dx.doi.org/10.3389/fimmu.2018.01299
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author Guo, Yi
Tian, Xin
Wang, Xuefeng
Xiao, Zheng
author_facet Guo, Yi
Tian, Xin
Wang, Xuefeng
Xiao, Zheng
author_sort Guo, Yi
collection PubMed
description Immunoglobulin has been widely used in a variety of diseases, including primary and secondary immunodeficiency diseases, neuromuscular diseases, and Kawasaki disease. Although a large number of clinical trials have demonstrated that immunoglobulin is effective and well tolerated, various adverse effects have been reported. The majority of these events, such as flushing, headache, malaise, fever, chills, fatigue and lethargy, are transient and mild. However, some rare side effects, including renal impairment, thrombosis, arrhythmia, aseptic meningitis, hemolytic anemia, and transfusion-related acute lung injury (TRALI), are serious. These adverse effects are associated with specific immunoglobulin preparations and individual differences. Performing an early assessment of risk factors, infusing at a slow rate, premedicating, and switching from intravenous immunoglobulin (IVIG) to subcutaneous immunoglobulin (SCIG) can minimize these adverse effects. Adverse effects are rarely disabling or fatal, treatment mainly involves supportive measures, and the majority of affected patients have a good prognosis.
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spelling pubmed-60086532018-06-27 Adverse Effects of Immunoglobulin Therapy Guo, Yi Tian, Xin Wang, Xuefeng Xiao, Zheng Front Immunol Immunology Immunoglobulin has been widely used in a variety of diseases, including primary and secondary immunodeficiency diseases, neuromuscular diseases, and Kawasaki disease. Although a large number of clinical trials have demonstrated that immunoglobulin is effective and well tolerated, various adverse effects have been reported. The majority of these events, such as flushing, headache, malaise, fever, chills, fatigue and lethargy, are transient and mild. However, some rare side effects, including renal impairment, thrombosis, arrhythmia, aseptic meningitis, hemolytic anemia, and transfusion-related acute lung injury (TRALI), are serious. These adverse effects are associated with specific immunoglobulin preparations and individual differences. Performing an early assessment of risk factors, infusing at a slow rate, premedicating, and switching from intravenous immunoglobulin (IVIG) to subcutaneous immunoglobulin (SCIG) can minimize these adverse effects. Adverse effects are rarely disabling or fatal, treatment mainly involves supportive measures, and the majority of affected patients have a good prognosis. Frontiers Media S.A. 2018-06-08 /pmc/articles/PMC6008653/ /pubmed/29951056 http://dx.doi.org/10.3389/fimmu.2018.01299 Text en Copyright © 2018 Guo, Tian, Wang and Xiao. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Guo, Yi
Tian, Xin
Wang, Xuefeng
Xiao, Zheng
Adverse Effects of Immunoglobulin Therapy
title Adverse Effects of Immunoglobulin Therapy
title_full Adverse Effects of Immunoglobulin Therapy
title_fullStr Adverse Effects of Immunoglobulin Therapy
title_full_unstemmed Adverse Effects of Immunoglobulin Therapy
title_short Adverse Effects of Immunoglobulin Therapy
title_sort adverse effects of immunoglobulin therapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008653/
https://www.ncbi.nlm.nih.gov/pubmed/29951056
http://dx.doi.org/10.3389/fimmu.2018.01299
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