Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice

Physiologically based pharmacokinetic modelling (PBPK) is a powerful tool to predict in vivo pharmacokinetics based on physiological parameters and data from in vivo studies and in vitro assays. In vivo PBPK modelling in laboratory animals by noninvasive imaging could help to improve the in vivo-in...

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Detalles Bibliográficos
Autores principales: Taddio, Marco F., Mu, Linjing, Keller, Claudia, Schibli, Roger, Krämer, Stefanie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008768/
https://www.ncbi.nlm.nih.gov/pubmed/29967572
http://dx.doi.org/10.1155/2018/5849047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008768/
https://www.ncbi.nlm.nih.gov/pubmed/29967572
http://dx.doi.org/10.1155/2018/5849047

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