PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs

BACKGROUND: Platelet-derived growth factor (PDGF)-BB and its receptor PDGFR are highly expressed in pulmonary hypertension (PH) and mediate proliferation. Recently, we showed that PDGF-BB contracts pulmonary veins (PVs) and that this contraction is prevented by inhibition of PDGFR-β (imatinib/SU6668...

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Detalles Bibliográficos
Autores principales: Rieg, Annette D., Suleiman, Said, Anker, Carolin, Verjans, Eva, Rossaint, Rolf, Uhlig, Stefan, Martin, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009037/
https://www.ncbi.nlm.nih.gov/pubmed/29921306
http://dx.doi.org/10.1186/s12931-018-0829-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009037/
https://www.ncbi.nlm.nih.gov/pubmed/29921306
http://dx.doi.org/10.1186/s12931-018-0829-5

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