Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls,...

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Detalles Bibliográficos
Autores principales: Kelada, Mark, Walsh, John M D, Devine, Robert W, McArdle, Patrick, Stephens, John C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009099/
https://www.ncbi.nlm.nih.gov/pubmed/29977390
http://dx.doi.org/10.3762/bjoc.14.104
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author Kelada, Mark
Walsh, John M D
Devine, Robert W
McArdle, Patrick
Stephens, John C
author_facet Kelada, Mark
Walsh, John M D
Devine, Robert W
McArdle, Patrick
Stephens, John C
author_sort Kelada, Mark
collection PubMed
description A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.
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spelling pubmed-60090992018-07-05 Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation Kelada, Mark Walsh, John M D Devine, Robert W McArdle, Patrick Stephens, John C Beilstein J Org Chem Letter A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups. Beilstein-Institut 2018-05-28 /pmc/articles/PMC6009099/ /pubmed/29977390 http://dx.doi.org/10.3762/bjoc.14.104 Text en Copyright © 2018, Kelada et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Kelada, Mark
Walsh, John M D
Devine, Robert W
McArdle, Patrick
Stephens, John C
Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation
title Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation
title_full Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation
title_fullStr Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation
title_full_unstemmed Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation
title_short Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation
title_sort synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009099/
https://www.ncbi.nlm.nih.gov/pubmed/29977390
http://dx.doi.org/10.3762/bjoc.14.104
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