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The first Pd-catalyzed Buchwald–Hartwig aminations at C-2 or C-4 in the estrone series
A facile Pd-catalyzed C(sp(2))–N coupling to provide a range of 2- or 4-[(subst.)phenyl]amino-13α-estrone derivatives has been achieved under microwave irradiation. The reactions were mediated with the use of Pd(OAc)(2) as a catalyst and KOt-Bu as a base in the presence of X-Phos as a ligand. The de...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009172/ https://www.ncbi.nlm.nih.gov/pubmed/29977371 http://dx.doi.org/10.3762/bjoc.14.85 |