Mechanisms by which Human Cells Bypass Damaged Bases during DNA Replication after Ultraviolet Irradiation

The replication of damaged DNA involves cascading mechanisms of increasing complexity but decreasing accuracy. The most accurate mechanism uses low-fidelity DNA polymerases, Pol H and Pol I, which have active sites sufficiently large to accommodate a pyrimidine dimer. Replicative bypass of DNA damag...

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Detalles Bibliográficos
Autor principal: Cleaver, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2002
Materias:
Mini-Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009260/
https://www.ncbi.nlm.nih.gov/pubmed/12805912
http://dx.doi.org/10.1100/tsw.2002.348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009260/
https://www.ncbi.nlm.nih.gov/pubmed/12805912
http://dx.doi.org/10.1100/tsw.2002.348

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