Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

Carbonic anhydrase (CA) IX is a hypoxia inducible enzyme that is highly expressed in solid tumours. Therefore, it has been considered as an anticancer target using specific chemical inhibitors. The nitroimidazoles DTP338 and DTP348 have been shown to inhibit CA IX in nanomolar range in vitro and red...

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Detalles Bibliográficos
Autores principales: Aspatwar, Ashok, Becker, Holger M., Parvathaneni, Nanda Kumar, Hammaren, Milka, Svorjova, Aleksandra, Barker, Harlan, Supuran, Claudiu T., Dubois, Ludwig, Lambin, Philippe, Parikka, Mataleena, Parkkila, Seppo, Winum, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009478/
https://www.ncbi.nlm.nih.gov/pubmed/29909747
http://dx.doi.org/10.1080/14756366.2018.1482285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009478/
https://www.ncbi.nlm.nih.gov/pubmed/29909747
http://dx.doi.org/10.1080/14756366.2018.1482285

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